Galerians Ash. Japanese and US versions.
http://oi46.tinypic.com/263cxmv.jpg
http://oi50.tinypic.com/2lt0dk.jpg
This one is strange, since I actually really love the original artwork for the Galerians games. But despite that, I can't help but like the US cover better on this one.
Despite being a nice bit of character artwork, the Japanese one just feels like it lacks much offhand impact. To me at least, it doesn't feel like it would stand out from the crowd, and make you want to check it out just based on the box art. A little too much white in there, and the colors present are a bit too neutral. It's a nice piece when you single it out and really look at it, but on a shelf full of games, it probably wouldn't make much of an impression.
The US boxart is a bit more mysterious though, with kind of an odd, creepy edge to it, and a good little splash of color. Kind of a sense of menace to it, and I love that. Come to think of it, it was probably this piece of boxart that made me want to check the series out to begin with.