I have a save specifically for when I want to replay it because I consider it one of gamings biggest milestones and achievements.
Before, it always made me sad, but last night I did it for the first time with the knowledge we are getting Shenmue III, and it made me really, really happy. I was happy seeing all of these questions and stuff that I may actually get answers to. Shenhua talks about water buffalo, and life in Bailu, and the old lady who taught her how to sew, all this stuff that's hinted in 3 you think you'll never see ever. And we're fucking getting it. We're actually going to get it! Every time I played this section of the game I had a sense of melancholy, but for the first time I could sit back and enjoy it in full without pressure that I will never get answers to my questions.
I highly suggest everyone else do the same. What an amazing experience!